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cAMP Microdomains and EPAC Signaling Beyond PKA, elevated cAMP activates Exchange Protein directly Activated by cAMP (EPAC2) in beta-cells

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Tirzepatide side effects (Phase 3 data) Nausea: 24-33% of participants (dose-dependent) Diarrhea: 18-23% Vomiting: 8-13% Constipation: 11-17% Discontinuation due to adverse events: 4.3-7.1% Serious adverse events: similar to placebo The difference in discontinuation rates is striking